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KMID : 1134819970260040689
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Journal of the Korean Society of Food Science and Nutrition
1997 Volume.26 No. 4 p.689 ~ p.696
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Effects of Aralia canescens and Phellodendron amurense Extracts on Streptozotocin Induced Diabetic ICR Mice
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Seo So-Young
Kim Harriet
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Abstract
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The effects of Aralia canescens and Phellodendron amurense(AP) extracts on the experimental diabetes in ICR mice were investigated. 96 male ICR mice were induced diabetes mellitus by intraperitoneal streptozotocin injection(75㎎/㎏ B.W.) and divided into two injection groups which are 5 day injection and 10 day injection group. Then, each injection group was subdivided into 8 groups of 6 animals repspectively. CIC served as control and CI1, CI2 and CI3 were treated with 50, 150, 250㎎/㎏ B.W. of AP extracts powder in 0.9% NaCl solution. Animals of groups DIC, DIl, DI2 and DI3 were streptozotocin-induced diabetes. DIC served as diabetic control and the rest groups received 50, 150, 250㎎/㎏ B.W. of AP extracts powder in saline solution respectively. The body weight, liver and kiney weight changes and blood levels of glucose, cholesterol and triglyceride were measured. Thiobarbituric acid reactive substance(TBARS), and glutathione reductase(GR) and glutathione peroxidase(GPx) activities were also measured for determining antioxidant effects. AP extracts increased the body weight in diabetic groups. The liver and kidney weight/100g B.W. in DIC group were greater than those of normal ICR group but after AP extracts injection, liver and kidney weight were decreased significantly. These effects were more efficient at 10 days injection group. The total, LDL, VLDL cholesterol and triglyceride levels were significantly higher in DIC group and the extent of decrement responded to AP injection dose. The contents of TBARS and antioxidant enzyme activities were relatively decreased after AP extracts injection. These results suggest that the intraperitoneally administered AP extracts may have not only hypoglycemic effect but act as antioxidants by reducing lipid peroxidation.
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KEYWORD
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Aralia canescens, Phellodendron amurense, thiobarbituric acid reactive substance(TBARS), streptozotocin (STZ)-induced diabetic mice
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